Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

Mitochondrial Ca(2+) uptake has a key role in cellular Ca(2+) homeostasis. Excessive matrix Ca(2+) concentrations, especially when coincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conductance channel: the mitochondrial permeability transition pore (mPTP)...

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Detalles Bibliográficos
Autores principales: Briston, Thomas, Roberts, Malcolm, Lewis, Sian, Powney, Ben, M. Staddon, James, Szabadkai, Gyorgy, Duchen, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585167/
https://www.ncbi.nlm.nih.gov/pubmed/28874733
http://dx.doi.org/10.1038/s41598-017-10673-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585167/
https://www.ncbi.nlm.nih.gov/pubmed/28874733
http://dx.doi.org/10.1038/s41598-017-10673-8

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