Cell based assay identifies TLR2 and TLR4 stimulating impurities in Interferon beta

Immunogenicity can have devastating consequences on the safety and efficacy of therapeutic proteins. Therefore, evaluating and mitigating the risk of product immunogenicity is critical for the development these products. This study, showed that Betaseron and Extavia, which are reported to be more im...

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Detalles Bibliográficos
Autores principales: Haile, Lydia Asrat, Polumuri, Swamy Kumar, Rao, Roshni, Kelley-Baker, Logan, Kryndushkin, Dimitri, Rajaiah, Rajesh, Israely, Tomer, Rao, V. Ashutosh, Verthelyi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585229/
https://www.ncbi.nlm.nih.gov/pubmed/28874687
http://dx.doi.org/10.1038/s41598-017-09981-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585229/
https://www.ncbi.nlm.nih.gov/pubmed/28874687
http://dx.doi.org/10.1038/s41598-017-09981-w

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