Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost in HIV-1 and its precursors. Although both functions play key roles in l...

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Detalles Bibliográficos
Autores principales: Manrique, Santiago, Sauter, Daniel, Horenkamp, Florian A., Lülf, Sebastian, Yu, Hangxing, Hotter, Dominik, Anand, Kanchan, Kirchhoff, Frank, Geyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585231/
https://www.ncbi.nlm.nih.gov/pubmed/28874665
http://dx.doi.org/10.1038/s41467-017-00481-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585231/
https://www.ncbi.nlm.nih.gov/pubmed/28874665
http://dx.doi.org/10.1038/s41467-017-00481-z

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