Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and may function as a generalized bioscavenger by binding and/or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripheral nervous systems. Variants of BChE were rationa...

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Detalles Bibliográficos
Autores principales: Larrimore, Katherine E., Kazan, I. Can, Kannan, Latha, Kendle, R. Player, Jamal, Tameem, Barcus, Matthew, Bolia, Ashini, Brimijoin, Stephen, Zhan, Chang-Guo, Ozkan, S. Banu, Mor, Tsafrir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585256/
https://www.ncbi.nlm.nih.gov/pubmed/28874829
http://dx.doi.org/10.1038/s41598-017-10571-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585256/
https://www.ncbi.nlm.nih.gov/pubmed/28874829
http://dx.doi.org/10.1038/s41598-017-10571-z

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