Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ

Nosiheptide is a prototypal thiopeptide antibiotic, containing an indole side ring in addition to its thiopeptide-characteristic macrocylic scaffold. This indole ring is derived from 3-methyl-2-indolic acid (MIA), a product of the radical S-adenosylmethionine enzyme NosL, but how MIA is incorporated...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Wei, Ji, Wenjuan, Wu, Yujie, Wu, Runze, Liu, Wan-Qiu, Mo, Tianlu, Zhao, Junfeng, Ma, Xiaoyan, Zhang, Wei, Xu, Ping, Deng, Zixin, Tang, Boping, Yu, Yi, Zhang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585349/
https://www.ncbi.nlm.nih.gov/pubmed/28874663
http://dx.doi.org/10.1038/s41467-017-00439-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585349/
https://www.ncbi.nlm.nih.gov/pubmed/28874663
http://dx.doi.org/10.1038/s41467-017-00439-1

Ejemplares similares