Signalling strength determines proapoptotic functions of STING

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS–STING signalling pathway, which initiates a gene expression programme linked to cellular activation and cytokine production. W...

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Detalles Bibliográficos
Autores principales: Gulen, Muhammet F., Koch, Ute, Haag, Simone M., Schuler, Fabian, Apetoh, Lionel, Villunger, Andreas, Radtke, Freddy, Ablasser, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585373/
https://www.ncbi.nlm.nih.gov/pubmed/28874664
http://dx.doi.org/10.1038/s41467-017-00573-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585373/
https://www.ncbi.nlm.nih.gov/pubmed/28874664
http://dx.doi.org/10.1038/s41467-017-00573-w

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