Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney

The mitochondrial matrix protein cyclophilin D (CypD) is an essential component of the mitochondrial permeability transition pore (MPTP). Here we characterized the effects of CypD ablation on bioenergetics in the kidney. CypD loss triggers a metabolic shift in Ppif−/− male and female mouse kidneys t...

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Detalles Bibliográficos
Autores principales: Klawitter, Jelena, Pennington, Alexander, Klawitter, Jost, Thurman, Joshua M., Christians, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585384/
https://www.ncbi.nlm.nih.gov/pubmed/28874678
http://dx.doi.org/10.1038/s41598-017-10076-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585384/
https://www.ncbi.nlm.nih.gov/pubmed/28874678
http://dx.doi.org/10.1038/s41598-017-10076-9

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