Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease–Causing Mutation

BACKGROUND: Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) can recapitulate features of ion channel mutations causing inherited rhythm disease. However, the lack of maturity of these cells is considered a significant limitation of the model. Prolonged culture of hiPSC‐CMs pro...

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Detalles Bibliográficos
Autores principales: Veerman, Christiaan C., Mengarelli, Isabella, Lodder, Elisabeth M., Kosmidis, Georgios, Bellin, Milena, Zhang, Miao, Dittmann, Sven, Guan, Kaomei, Wilde, Arthur A. M., Schulze‐Bahr, Eric, Greber, Boris, Bezzina, Connie R., Verkerk, Arie O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586268/
https://www.ncbi.nlm.nih.gov/pubmed/28739862
http://dx.doi.org/10.1161/JAHA.116.005135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586268/
https://www.ncbi.nlm.nih.gov/pubmed/28739862
http://dx.doi.org/10.1161/JAHA.116.005135

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