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The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but subsequently inactivated in response to membrane...

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Detalles Bibliográficos
Autores principales: Shimizu, Takahiro, Higuchi, Taiga, Toba, Toshihiro, Ohno, Chie, Fujii, Takuto, Nilius, Bernd, Sakai, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586397/
https://www.ncbi.nlm.nih.gov/pubmed/28904867
http://dx.doi.org/10.1002/2211-5463.12273