Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

BACKGROUND: Compromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity‐based pathology in heart disease is just beginning. The molecular...

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Detalles Bibliográficos
Autores principales: Xu, Na, Bitan, Gal, Schrader, Thomas, Klärner, Frank‐Gerrit, Osinska, Hanna, Robbins, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586456/
https://www.ncbi.nlm.nih.gov/pubmed/28862927
http://dx.doi.org/10.1161/JAHA.117.006182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586456/
https://www.ncbi.nlm.nih.gov/pubmed/28862927
http://dx.doi.org/10.1161/JAHA.117.006182

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