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Use of Allosteric Targets in the Discovery of Safer Drugs
The need for drugs with fewer side effects cannot be overemphasized. Today, most drugs modify the actions of enzymes, receptors, transporters and other molecules by directly binding to their active (orthosteric) sites. However, orthosteric site configuration is similar in several proteins performing...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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S. Karger AG
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586781/ https://www.ncbi.nlm.nih.gov/pubmed/23711993 http://dx.doi.org/10.1159/000350417 |