Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells

Mutant Cu/Zn superoxide dismutase (SOD1) can confer its misfolding on wild-type SOD1 in living cells; the propagation of misfolding can also be transmitted between cells in vitro. Recent studies identified fluorescently-tagged SOD1(G85R) as a promiscuous substrate that is highly prone to aggregate b...

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Detalles Bibliográficos
Autores principales: Pokrishevsky, Edward, Hong, Ran Ha, Mackenzie, Ian R., Cashman, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587256/
https://www.ncbi.nlm.nih.gov/pubmed/28877271
http://dx.doi.org/10.1371/journal.pone.0184384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587256/
https://www.ncbi.nlm.nih.gov/pubmed/28877271
http://dx.doi.org/10.1371/journal.pone.0184384

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