Cryo-EM structure of the activated GLP-1 receptor in complex with G protein

Glucagon-like peptide-1 (GLP-1) is a hormone with essential roles in regulating insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated through binding to GLP-1R, a family B G protein-coupled receptor (GPCR) signaling primarily through the stimulatory G protein Gs. Family...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Sun, Bingfa, Feng, Dan, Hu, Hongli, Chu, Matthew, Qu, Qianhui, Tarrasch, Jeffrey T., Li, Shane, Kobilka, Tong Sun, Kobilka, Brian K., Skiniotis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587415/
https://www.ncbi.nlm.nih.gov/pubmed/28538729
http://dx.doi.org/10.1038/nature22394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587415/
https://www.ncbi.nlm.nih.gov/pubmed/28538729
http://dx.doi.org/10.1038/nature22394

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