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Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel

Voltage-dependent sodium channels are responsible of the rising phase of the action potential in excitable cells. These membrane integral proteins are composed by a pore-forming α-subunit, and one or more auxiliary β subunits. Mutation E87Q of the β1 subunit is correlated with Brugada syndrome, a ge...

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Detalles Bibliográficos
Autores principales: Baroni, Debora, Picco, Cristiana, Moran, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587543/
https://www.ncbi.nlm.nih.gov/pubmed/28878239
http://dx.doi.org/10.1038/s41598-017-10645-y