A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Jun, Ao, Ming-tao, Shao, Rui, Wang, Hui-ru, Yu, Diao, Fang, Mei-juan, Gao, Xiang, Wu, Zhen, Zhou, Qiang, Xue, Yu-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587564/
https://www.ncbi.nlm.nih.gov/pubmed/28878233
http://dx.doi.org/10.1038/s41598-017-10728-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587564/
https://www.ncbi.nlm.nih.gov/pubmed/28878233
http://dx.doi.org/10.1038/s41598-017-10728-w

Ejemplares similares