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A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number...

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Detalles Bibliográficos
Autores principales:	Wu, Jun, Ao, Ming-tao, Shao, Rui, Wang, Hui-ru, Yu, Diao, Fang, Mei-juan, Gao, Xiang, Wu, Zhen, Zhou, Qiang, Xue, Yu-hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587564/ https://www.ncbi.nlm.nih.gov/pubmed/28878233 http://dx.doi.org/10.1038/s41598-017-10728-w

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