Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure. We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP. Here, we found that the expression level and activity of SHIP...

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Detalles Bibliográficos
Autores principales: Saurus, Pauliina, Tolvanen, Tuomas A., Lindfors, Sonja, Kuusela, Sara, Holthöfer, Harry, Lehtonen, Eero, Lehtonen, Sanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587593/
https://www.ncbi.nlm.nih.gov/pubmed/28878342
http://dx.doi.org/10.1038/s41598-017-10512-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587593/
https://www.ncbi.nlm.nih.gov/pubmed/28878342
http://dx.doi.org/10.1038/s41598-017-10512-w

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