Cargando…

Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway

Transglutaminase 2 (TG2) performs multiple reactions, including transamidation, and also plays a role in signal transduction as a GTP-binding protein. In this study, we reveal that TG2 controls osteoclast differentiation and bone homeostasis in mice. Osteoclasts specifically expressed the TG2 isofor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Woo-Shin, Kim, Haemin, Jeong, Eui Man, Kim, Hyung Joon, Lee, Zang Hee, Kim, In-Gyu, Kim, Hong-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587636/ https://www.ncbi.nlm.nih.gov/pubmed/28878266 http://dx.doi.org/10.1038/s41598-017-11246-5

Ejemplares similares

Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation
por: Park, So Jeong, et al.
Publicado: (2016)

Active repression by Blimp1 play an important role in osteoclast differentiation
por: Nishikawa, Keizo, et al.
Publicado: (2012)

Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis
por: Jeong, Eui Man, et al.
Publicado: (2016)

Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism
por: Kim, Haemin, et al.
Publicado: (2021)

Intimal Hyperplasia in Loop-Injured Carotid Arteries Is Attenuated in Transglutaminase 2-Null Mice
por: Min, Seung-Kee, et al.
Publicado: (2014)

Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival
por: Kim, Hyung Joon, et al.
Publicado: (2012)

Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs
por: Cho, Sung-Yup, et al.
Publicado: (2020)

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis
por: Miyauchi, Yoshiteru, et al.
Publicado: (2010)

Double-Stranded RNA Enhances Matrix Metalloproteinase-1 and -13 Expressions through TLR3-Dependent Activation of Transglutaminase 2 in Dermal Fibroblasts
por: Hong, Ah-Young, et al.
Publicado: (2022)

Supporting data for the effect of gamma-secretase inhibitors in osteoclast differentiation and spreading
por: Jin, Won Jong, et al.
Publicado: (2016)

Signaling Pathways in Osteoclast Differentiation
por: Kim, Jung Ha, et al.
Publicado: (2016)

Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production
por: Lee, Seok-Jin, et al.
Publicado: (2017)

Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
por: Oh, Keunhee, et al.
Publicado: (2011)

Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation
por: LEE, JIN-HAENG, et al.
Publicado: (2014)

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation
por: Kim, Gyeong-Ji, et al.
Publicado: (2020)

S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes
por: Jeong, Eui Man, et al.
Publicado: (2018)

Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity
por: Ha, Hyun Ji, et al.
Publicado: (2018)

Stimulation of osteoclast migration and bone resorption by C–C chemokine ligands 19 and 21
por: Lee, Jiyeon, et al.
Publicado: (2017)

Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding protein–protein interactions of the fused protein
por: Kim, Hyo-Jun, et al.
Publicado: (2021)

Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2
por: Jeong, Eui Man, et al.
Publicado: (2020)

Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways
por: Ihn, Hye Jung, et al.
Publicado: (2017)

Blimp-1 and systemic lupus erythematosus
por: Diamond, Betty, et al.
Publicado: (2014)

Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis
por: Kim, Hyung Joon, et al.
Publicado: (2019)

S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis
por: Kim, Haemin, et al.
Publicado: (2019)

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption
por: Jang, Jin Sun, et al.
Publicado: (2019)

Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells
por: Kim, Bong Gyu, et al.
Publicado: (2010)

Rhus javanica Gall Extract Inhibits the Differentiation of Bone Marrow-Derived Osteoclasts and Ovariectomy-Induced Bone Loss
por: Kim, Tae-Ho, et al.
Publicado: (2016)

Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation
por: Choi, Sik-Won, et al.
Publicado: (2013)

Effect of remifentanil on pre-osteoclast cell differentiation in vitro
por: Jeon, Hyun-Ook, et al.
Publicado: (2018)

Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption
por: Lee, So-Youn, et al.
Publicado: (2018)

The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway
por: Lee, Yong Deok, et al.
Publicado: (2020)

Diphlorethohydroxycarmalol from Ishige okamurae Suppresses Osteoclast Differentiation by Downregulating the NF-κB Signaling Pathway
por: Ihn, Hye Jung, et al.
Publicado: (2017)

Crystal Structure of Transglutaminase 2 with GTP Complex and Amino Acid Sequence Evidence of Evolution of GTP Binding Site
por: Jang, Tae-Ho, et al.
Publicado: (2014)

Tolerogenic function of Blimp-1 in dendritic cells
por: Kim, Sun Jung, et al.
Publicado: (2011)

Tolerogenic function of Blimp-1 in dendritic cells
por: Kim, Sun Jung, et al.
Publicado: (2012)

Keratinocyte transglutaminase 2 promotes CCR6(+) γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation
por: Shin, Ji-Woong, et al.
Publicado: (2020)

Synchronized Cell Cycle Arrest Promotes Osteoclast Differentiation
por: Kwon, Minsuk, et al.
Publicado: (2016)

Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-κB Signaling Pathways
por: Lee, Jiyeon, et al.
Publicado: (2014)

Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition
por: Lee, Seon-Hyeong, et al.
Publicado: (2018)

Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression
por: Kim, Eun-Jung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q8v2ott04fbfvulgdufeu98led