Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we show that upregulating Drp1—a Dynamin-related protein that promotes mitochondrial fission—in midlife, prolongs Drosophila...

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Detalles Bibliográficos
Autores principales: Rana, Anil, Oliveira, Matheus P., Khamoui, Andy V., Aparicio, Ricardo, Rera, Michael, Rossiter, Harry B., Walker, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587646/
https://www.ncbi.nlm.nih.gov/pubmed/28878259
http://dx.doi.org/10.1038/s41467-017-00525-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587646/
https://www.ncbi.nlm.nih.gov/pubmed/28878259
http://dx.doi.org/10.1038/s41467-017-00525-4

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