The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

In Saccharomyces cerevisiae, deletion of large ribosomal subunit protein-encoding genes increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key transcriptional activator of amino acid biosynthesis genes, increases lifespan, is unknown. Here we show that Gcn4 acts as a...

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Detalles Bibliográficos
Autores principales: Mittal, Nitish, Guimaraes, Joao C., Gross, Thomas, Schmidt, Alexander, Vina-Vilaseca, Arnau, Nedialkova, Danny D., Aeschimann, Florian, Leidel, Sebastian A., Spang, Anne, Zavolan, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587724/
https://www.ncbi.nlm.nih.gov/pubmed/28878244
http://dx.doi.org/10.1038/s41467-017-00539-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587724/
https://www.ncbi.nlm.nih.gov/pubmed/28878244
http://dx.doi.org/10.1038/s41467-017-00539-y

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