Cargando…

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu

While most DNA polymerases discriminate against ribonucleotide triphosphate (rNTP) incorporation very effectively, the Family X member DNA polymerase μ (Pol μ) incorporates rNTPs almost as efficiently as deoxyribonucleotides. To gain insight into how this occurs, here we have used X-ray crystallogra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moon, Andrea F., Pryor, John M., Ramsden, Dale A., Kunkel, Thomas A., Bebenek, Katarzyna, Pedersen, Lars C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587726/ https://www.ncbi.nlm.nih.gov/pubmed/28911097 http://dx.doi.org/10.1093/nar/gkx527

Ejemplares similares

The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ
por: Gosavi, Rajendrakumar A., et al.
Publicado: (2012)

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
por: Kaminski, Andrea M., et al.
Publicado: (2020)

Structure–Function Studies of DNA Polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2014)

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
por: Crespan, Emmanuele, et al.
Publicado: (2016)

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA
por: Lazzaro, Federico, et al.
Publicado: (2012)

Scrunching During DNA Repair Synthesis
por: Garcia-Diaz, Miguel, et al.
Publicado: (2009)

A polar filter in DNA polymerases prevents ribonucleotide incorporation
por: Johnson, Mary K, et al.
Publicado: (2019)

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
por: Jamsen, Joonas A., et al.
Publicado: (2017)

Genome instability due to ribonucleotide incorporation into DNA
por: Nick McElhinny, Stephanie A., et al.
Publicado: (2010)

Structural Insights into the Specificity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass by Family X DNA Polymerases
por: Kaminski, Andrea M., et al.
Publicado: (2021)

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining
por: Kaminski, Andrea M., et al.
Publicado: (2022)

The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity
por: Donigan, Katherine A., et al.
Publicado: (2014)

Promiscuous mismatch extension by human DNA polymerase lambda
por: Picher, Angel J., et al.
Publicado: (2006)

Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide
por: Singh, Isha, et al.
Publicado: (2018)

Kinetic Mechanisms Governing Stable Ribonucleotide Incorporation in Individual DNA Polymerase Complexes
por: Dahl, Joseph M., et al.
Publicado: (2014)

Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction
por: Westblade, Lars F., et al.
Publicado: (2010)

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2008)

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation
por: Clausen, Anders R., et al.
Publicado: (2015)

ATP enhances the error-prone ribonucleotide incorporation by the SARS-CoV-2 RNA polymerase
por: Pourfarjam, Yasin, et al.
Publicado: (2022)

Delineation of structural domains and identification of functionally important residues in DNA repair enzyme exonuclease VII
por: Poleszak, Katarzyna, et al.
Publicado: (2012)

Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
por: Mentegari, Elisa, et al.
Publicado: (2017)

Loop 1 modulates the fidelity of DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2010)

Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example
por: Oyala, Paul H., et al.
Publicado: (2016)

Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda
por: Burak, Matthew J., et al.
Publicado: (2015)

A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis
por: Juárez, Raquel, et al.
Publicado: (2006)

The Incorporation of Ribonucleotides Induces Structural and Conformational Changes in DNA
por: Meroni, Alice, et al.
Publicado: (2017)

Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases
por: Xu, Penghao, et al.
Publicado: (2021)

Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η
por: Sassa, Akira, et al.
Publicado: (2019)

Defining the RNaseH2 enzyme-initiated ribonucleotide excision repair pathway in Archaea
por: Heider, Margaret R., et al.
Publicado: (2017)

Incorporation of Orotic Acid into Ribonucleotides and Ribonucleic Acid by Liver Tumours
por: Reid, E.
Publicado: (1958)

Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA
por: Sassa, Akira, et al.
Publicado: (2019)

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase
por: Lu, Gaofei, et al.
Publicado: (2018)

Ribonucleotide reductases: essential enzymes for bacterial life
por: Torrents, Eduard
Publicado: (2014)

Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
por: Chen, Yongheng, et al.
Publicado: (2013)

Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases
por: Riva, Valentina, et al.
Publicado: (2020)

Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation
por: Ordonez, Heather, et al.
Publicado: (2014)

Evaluation of repair activity by quantification of ribonucleotides in the genome
por: Iida, Tetsushi, et al.
Publicado: (2021)

A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23
por: Dhaliwal, Balvinder, et al.
Publicado: (2014)

Ribonucleotides embedded in template DNA impair mitochondrial RNA polymerase progression
por: Singh, Meenakshi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j7c0p5im31pue0k2ur5bmrepm8