Synthesis and incorporation of (13)C-labeled DNA building blocks to probe structural dynamics of DNA by NMR

We report the synthesis of atom-specifically (13)C-modified building blocks that can be incorporated into DNA via solid phase synthesis to facilitate investigations on structural and dynamic features via NMR spectroscopy. In detail, 6-(13)C-modified pyrimidine and 8-(13)C purine DNA phosphoramidites...

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Detalles Bibliográficos
Autores principales: Nußbaumer, Felix, Juen, Michael Andreas, Gasser, Catherina, Kremser, Johannes, Müller, Thomas, Tollinger, Martin, Kreutz, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587810/
https://www.ncbi.nlm.nih.gov/pubmed/28911104
http://dx.doi.org/10.1093/nar/gkx592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587810/
https://www.ncbi.nlm.nih.gov/pubmed/28911104
http://dx.doi.org/10.1093/nar/gkx592

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