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Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences

Mitochondrial endonuclease G from Leishmania infantum (LiEndoG) participates in the degradation of double-stranded DNA (dsDNA) during parasite cell death and is catalytically inactive at a pH of 8.0 or above. The presence, in the primary sequence, of an acidic amino acid-rich insertion exclusive to...

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Detalles Bibliográficos
Autores principales: Oliva, Cristina, Sánchez-Murcia, Pedro A., Rico, Eva, Bravo, Ana, Menéndez, Margarita, Gago, Federico, Jiménez-Ruiz, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587815/
https://www.ncbi.nlm.nih.gov/pubmed/28911117
http://dx.doi.org/10.1093/nar/gkx629