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Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences

Mitochondrial endonuclease G from Leishmania infantum (LiEndoG) participates in the degradation of double-stranded DNA (dsDNA) during parasite cell death and is catalytically inactive at a pH of 8.0 or above. The presence, in the primary sequence, of an acidic amino acid-rich insertion exclusive to...

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Detalles Bibliográficos
Autores principales:	Oliva, Cristina, Sánchez-Murcia, Pedro A., Rico, Eva, Bravo, Ana, Menéndez, Margarita, Gago, Federico, Jiménez-Ruiz, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587815/ https://www.ncbi.nlm.nih.gov/pubmed/28911117 http://dx.doi.org/10.1093/nar/gkx629

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