Cargando…

Dichloroacetate induces protective autophagy in esophageal squamous carcinoma cells

Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase, which promotes the flux of carbohydrates into mitochondria and enhances the aerobic oxidation of glucose. DCA has previously been demonstrated to exhibit antitumor properties. The present study revealed that treatment with DCA i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Hong-Yu, Wang, He-Nan, Xia, Feng-Yu, Sun, Yan, Liu, Hong-Li, Yan, Li-Li, Li, Shan-Shan, Jiang, Dong-Chun, Xu, Mei-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588168/ https://www.ncbi.nlm.nih.gov/pubmed/28928817 http://dx.doi.org/10.3892/ol.2017.6562

Ejemplares similares

Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels
por: Dong, Gaochao, et al.
Publicado: (2016)

Correlation of CD146 expression and clinicopathological characteristics in esophageal squamous cell carcinoma
por: LI, YAN, et al.
Publicado: (2014)

Combined detection of serum Dickkopf‐1 and its autoantibodies to diagnose esophageal squamous cell carcinoma
por: Peng, Yu‐Hui, et al.
Publicado: (2016)

Novel ammonium dichloroacetates with enhanced herbicidal activity for weed control
por: Li, Huanhuan, et al.
Publicado: (2020)

A Panel of Overexpressed Proteins for Prognosis in Esophageal Squamous Cell Carcinoma
por: Shang, Li, et al.
Publicado: (2014)

MicroRNA-181a promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma via the TGF-β/Smad pathway
por: Xu, Run, et al.
Publicado: (2021)

Dichloroacetate induces autophagy in colorectal cancer cells and tumours
por: Lin, G, et al.
Publicado: (2014)

Expressions of the γ(2) chain of laminin-5 and secreted protein acidic and rich in cysteine in esophageal squamous cell carcinoma and their relation to prognosis
por: Xue, Li-Yan, et al.
Publicado: (2011)

Dichloroacetate ameliorates myocardial ischemia-reperfusion injury via regulating autophagy and glucose homeostasis
por: Li, Shuo, et al.
Publicado: (2019)

Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells
por: Li, Bo, et al.
Publicado: (2016)

Role of matrix metalloproteinase-9 in transforming growth factor-β1-induced epithelial–mesenchymal transition in esophageal squamous cell carcinoma
por: Bai, Xue, et al.
Publicado: (2017)

Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma
por: Li, Lan, et al.
Publicado: (2017)

The prognostic effect of perineural invasion in esophageal squamous cell carcinoma
por: Chen, Jie-Wei, et al.
Publicado: (2014)

Chaperone‐mediated autophagy affects tumor cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma
por: Cao, Dujuan, et al.
Publicado: (2021)

Endoscopic Ultrasound for Preoperative Esophageal Squamous Cell Carcinoma: a Meta-Analysis
por: Luo, Lin-na, et al.
Publicado: (2016)

Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells
por: Li, Bo, et al.
Publicado: (2017)

Superior anti-tumor efficacy of diisopropylamine dichloroacetate compared with dichloroacetate in a subcutaneous transplantation breast tumor model
por: Su, Lei, et al.
Publicado: (2016)

Upregulation of METTL3 Expression Predicts Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma
por: Xia, Tian-Liang, et al.
Publicado: (2020)

Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma
por: Huang, Shan, et al.
Publicado: (2023)

Clinical pharmacology and toxicology of dichloroacetate.
por: Stacpoole, P W, et al.
Publicado: (1998)

Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells
por: Cheng, Xiao-Yu, et al.
Publicado: (2017)

Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer
por: Lu, Xiao, et al.
Publicado: (2018)

Tissue microarray analysis reveals a tight correlation between protein expression pattern and progression of esophageal squamous cell carcinoma
por: Xue, Li-yan, et al.
Publicado: (2006)

Crystal structure of diisopropylaminium dichloroacetate
por: Sun, Wei, et al.
Publicado: (2015)

TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1
por: Li, Juan, et al.
Publicado: (2022)

Mefloquine Inhibits Esophageal Squamous Cell Carcinoma Tumor Growth by Inducing Mitochondrial Autophagy
por: Xie, Yifei, et al.
Publicado: (2020)

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
por: Cao, Yu-Fei, et al.
Publicado: (2022)

Aberrant methylation of EYA4 promotes epithelial‐mesenchymal transition in esophageal squamous cell carcinoma
por: Luo, Mei, et al.
Publicado: (2018)

Autoantibodies as Potential Biomarkers for the Early Detection of Esophageal Squamous Cell Carcinoma
por: Xu, Yi-Wei, et al.
Publicado: (2014)

Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
por: Chen, Xi-Xi, et al.
Publicado: (2017)

Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma
por: Lu, Zhaoming, et al.
Publicado: (2021)

Anaerobic Microbial Metabolism of Dichloroacetate
por: Chen, Gao, et al.
Publicado: (2021)

Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy
por: Xia, Di, et al.
Publicado: (2020)

DNA Methylation Status of PAX1 and ZNF582 in Esophageal Squamous Cell Carcinoma
por: Huang, Jin, et al.
Publicado: (2017)

ESM1 Is a Promising Therapeutic Target and Prognostic Indicator for Esophageal Carcinogenesis/Esophageal Squamous Cell Carcinoma
por: Li, Juan, et al.
Publicado: (2022)

1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 2,2-dichloroacetate
por: Yu, Yan-Hong, et al.
Publicado: (2009)

MiR-126 promotes esophageal squamous cell carcinoma via inhibition of apoptosis and autophagy
por: Li, Mingli, et al.
Publicado: (2020)

Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma
por: Meng, Gang, et al.
Publicado: (2019)

CEP55 Positively Affects Tumorigenesis of Esophageal Squamous Cell Carcinoma and Is Correlated with Poor Prognosis
por: Yan, Shu-Mei, et al.
Publicado: (2021)

Quantitative immunohistochemistry (IHC) analysis of biomarker combinations for human esophageal squamous cell carcinoma
por: Gao, Jiebing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v4qi3kalmqvhdbhst34mkbrcm5