Membrane‐bound Dickkopf‐1 in Foxp3(+) regulatory T cells suppresses T‐cell‐mediated autoimmune colitis

Induction of tolerance is a key mechanism to maintain or to restore immunological homeostasis. Here we show that Foxp3(+) regulatory T (Treg) cells use Dickkopf‐1 (DKK‐1) to regulate T‐cell‐mediated tolerance in the T‐cell‐mediated autoimmune colitis model. Treg cells from DKK‐1 hypomorphic doubleri...

Descripción completa

Detalles Bibliográficos
Autores principales: Chae, Wook‐Jin, Park, Jong‐Hyun, Henegariu, Octavian, Yilmaz, Saliha, Hao, Liming, Bothwell, Alfred L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588763/
https://www.ncbi.nlm.nih.gov/pubmed/28556921
http://dx.doi.org/10.1111/imm.12766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588763/
https://www.ncbi.nlm.nih.gov/pubmed/28556921
http://dx.doi.org/10.1111/imm.12766

Ejemplares similares