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pH-dependent binding of guests in the cavity of a polyhedral coordination cage: reversible uptake and release of drug molecules

A range of organic molecules with acidic or basic groups exhibit strong pH-dependent binding inside the cavity of a polyhedral coordination cage. Guest binding in aqueous solution is dominated by a hydrophobic contribution which is compensated by stronger solvation when the guests become cationic (b...

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Detalles Bibliográficos
Autores principales: Cullen, William, Turega, Simon, Hunter, Christopher A., Ward, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588781/
https://www.ncbi.nlm.nih.gov/pubmed/28936311
http://dx.doi.org/10.1039/c4sc02090a