Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission. We isolated, synthesized and pharmacologically characterized Cd1a, a novel peptide from...

Descripción completa

Detalles Bibliográficos
Autores principales: Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F., Lewis, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589098/
https://www.ncbi.nlm.nih.gov/pubmed/28880874
http://dx.doi.org/10.1371/journal.pone.0182848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589098/
https://www.ncbi.nlm.nih.gov/pubmed/28880874
http://dx.doi.org/10.1371/journal.pone.0182848

Ejemplares similares