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Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi
Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission. We isolated, synthesized and pharmacologically characterized Cd1a, a novel peptide from...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589098/ https://www.ncbi.nlm.nih.gov/pubmed/28880874 http://dx.doi.org/10.1371/journal.pone.0182848 |