SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions

We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells and melanoma cells in vitro, gastrointestinal stromal tumors, human sun-exposed skin, and myenteric plexus of human colon post-fasting in vivo. This is the first repo...

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Detalles Bibliográficos
Autores principales: Chen, Lei L., Zhu, Jing, Schumacher, Jonathan, Wei, Chongjuan, Ramdas, Latha, Prieto, Victor G., Jimenez, Arnie, Velasco, Marco A., Tripp, Sheryl R., Andtbacka, Robert H. I., Gouw, Launce, Rodgers, George M., Zhang, Liansheng, Chan, Benjamin K., Cassidy, Pamela B., Benjamin, Robert S., Leachman, Sancy A., Frazier, Marsha L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589172/
https://www.ncbi.nlm.nih.gov/pubmed/28880927
http://dx.doi.org/10.1371/journal.pone.0184154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589172/
https://www.ncbi.nlm.nih.gov/pubmed/28880927
http://dx.doi.org/10.1371/journal.pone.0184154

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