Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick

Mammalian prions, the pathogens that cause transmissible spongiform encephalopathies, propagate by self-perpetuating the structural information stored in the abnormally folded, aggregated conformer (PrP(Sc)) of the host-encoded prion protein (PrP(C)). To date, no structural model related to prion as...

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Detalles Bibliográficos
Autores principales: Igel-Egalon, Angélique, Moudjou, Mohammed, Martin, Davy, Busley, Alexandra, Knäpple, Tina, Herzog, Laetitia, Reine, Fabienne, Lepejova, Nad’a, Richard, Charles-Adrien, Béringue, Vincent, Rezaei, Human
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589264/
https://www.ncbi.nlm.nih.gov/pubmed/28880932
http://dx.doi.org/10.1371/journal.ppat.1006557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589264/
https://www.ncbi.nlm.nih.gov/pubmed/28880932
http://dx.doi.org/10.1371/journal.ppat.1006557

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