Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination. Here, we genetically disrupted key inhibitory components upst...

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Detalles Bibliográficos
Autores principales: Figlia, Gianluca, Norrmén, Camilla, Pereira, Jorge A, Gerber, Daniel, Suter, Ueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589416/
https://www.ncbi.nlm.nih.gov/pubmed/28880149
http://dx.doi.org/10.7554/eLife.29241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589416/
https://www.ncbi.nlm.nih.gov/pubmed/28880149
http://dx.doi.org/10.7554/eLife.29241

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