Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to proliferate in vivo. We sought to understand t...

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Detalles Bibliográficos
Autores principales: Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589418/
https://www.ncbi.nlm.nih.gov/pubmed/28826492
http://dx.doi.org/10.7554/eLife.27713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589418/
https://www.ncbi.nlm.nih.gov/pubmed/28826492
http://dx.doi.org/10.7554/eLife.27713

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