Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm

Janus tyrosine kinase 2 (JAK2) mediates downstream signaling of cytokine receptors in all hematological lineages, yet constitutively active JAK2 mutants are able to drive selective expansion of particular lineage(s) in myeloproliferative neoplasm (MPN). The molecular basis of lineage specificity is...

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Detalles Bibliográficos
Autores principales: Yao, Huiyu, Ma, Yue, Hong, Zhenya, Zhao, Lequn, Monaghan, Sara A., Hu, Ming-Chang, Huang, Lily Jun-shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589508/
https://www.ncbi.nlm.nih.gov/pubmed/28057939
http://dx.doi.org/10.1038/leu.2017.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589508/
https://www.ncbi.nlm.nih.gov/pubmed/28057939
http://dx.doi.org/10.1038/leu.2017.1

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