MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

The SET (I2PP2A) oncoprotein is a potent inhibitor of protein phosphatase 2A (PP2A) that regulates many cell processes and important signaling pathways. Despite the importance of SET overexpression and its prognostic impact in both hematologic and solid tumors, little is known about the mechanisms i...

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Detalles Bibliográficos
Autores principales: Pippa, Raffaella, Dominguez, Ana, Malumbres, Raquel, Endo, Akinori, Arriazu, Elena, Marcotegui, Nerea, Guruceaga, Elizabeth, Odero, María D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589557/
https://www.ncbi.nlm.nih.gov/pubmed/28903318
http://dx.doi.org/10.18632/oncotarget.9840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589557/
https://www.ncbi.nlm.nih.gov/pubmed/28903318
http://dx.doi.org/10.18632/oncotarget.9840

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