The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation

WHSC1L1/NSD3, one of the most aggressive human oncogenes, has two isoforms derived from alternative splicing. Overexpression of long or short NSD3 is capable of transforming a healthy into a cancer cell. NSD3s, the short isoform, contains only a PWWP domain, a histone methyl-lysine reader involved i...

Descripción completa

Detalles Bibliográficos
Autores principales: Rona, Germana B., Almeida, Diego S. G., Pinheiro, Anderson S., Eleutherio, Elis C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589563/
https://www.ncbi.nlm.nih.gov/pubmed/28903324
http://dx.doi.org/10.18632/oncotarget.11253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589563/
https://www.ncbi.nlm.nih.gov/pubmed/28903324
http://dx.doi.org/10.18632/oncotarget.11253

Ejemplares similares