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The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation
WHSC1L1/NSD3, one of the most aggressive human oncogenes, has two isoforms derived from alternative splicing. Overexpression of long or short NSD3 is capable of transforming a healthy into a cancer cell. NSD3s, the short isoform, contains only a PWWP domain, a histone methyl-lysine reader involved i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589563/ https://www.ncbi.nlm.nih.gov/pubmed/28903324 http://dx.doi.org/10.18632/oncotarget.11253 |