The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways

Gpbar1 (TGR5), a G-protein-coupled bile acid membrane receptor, is well known for its roles in regulation of glucose metabolism and energy homeostasis. In the current work, we found that TGR5 activation by its ligand suppressed lipopolysaccharide (LPS)-induced proinflammatory gene expression in wild...

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Detalles Bibliográficos
Autores principales: Su, Jia, Zhang, Qiqi, Qi, Hui, Wu, Linlin, Li, Yuanqiang, Yu, Donna, Huang, Wendong, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589588/
https://www.ncbi.nlm.nih.gov/pubmed/28903349
http://dx.doi.org/10.18632/oncotarget.17533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589588/
https://www.ncbi.nlm.nih.gov/pubmed/28903349
http://dx.doi.org/10.18632/oncotarget.17533

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