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The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways
Gpbar1 (TGR5), a G-protein-coupled bile acid membrane receptor, is well known for its roles in regulation of glucose metabolism and energy homeostasis. In the current work, we found that TGR5 activation by its ligand suppressed lipopolysaccharide (LPS)-induced proinflammatory gene expression in wild...
Autores principales: | Su, Jia, Zhang, Qiqi, Qi, Hui, Wu, Linlin, Li, Yuanqiang, Yu, Donna, Huang, Wendong, Chen, Wei-Dong, Wang, Yan-Dong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589588/ https://www.ncbi.nlm.nih.gov/pubmed/28903349 http://dx.doi.org/10.18632/oncotarget.17533 |
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