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Tumor location impacts immune response in mouse models of colon cancer

Existing preclinical models of human colorectal cancer (CRC) that rely on syngeneic subcutaneous grafts are problematic, because of increasing evidence that the immune microenvironment in subcutaneous tissue is significantly different from the gastrointestinal tract. Similarly, existing orthotopic m...

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Detalles Bibliográficos
Autores principales: Zhao, Xianda, Li, Lihua, Starr, Timothy K., Subramanian, Subbaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589620/
https://www.ncbi.nlm.nih.gov/pubmed/28903381
http://dx.doi.org/10.18632/oncotarget.18423