Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway

Methylglyoxal (MG), an extremely reactive glucose metabolite, exhibits antitumor activity. Glyoxalase I (GLOI), which catalyzes MG metabolism, is associated with the progression of human malignancies. While the roles of MG or GLOI have been demonstrated in some types of cancer, their effects in colo...

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Detalles Bibliográficos
Autores principales: Chen, Yuan, Fang, Lei, Li, Gefei, Zhang, Jiali, Li, Changxi, Ma, Mengni, Guan, Chen, Bai, Fumao, Lyu, Jianxin, Meng, Qing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589625/
https://www.ncbi.nlm.nih.gov/pubmed/28903386
http://dx.doi.org/10.18632/oncotarget.18601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589625/
https://www.ncbi.nlm.nih.gov/pubmed/28903386
http://dx.doi.org/10.18632/oncotarget.18601

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