Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1

DNA repair pathways present in all cells serve to preserve genome stability, but in cancer cells they also act reduce the efficacy of chemotherapy. The endonuclease ERCC1-XPF has an important role in the repair of DNA damage caused by a variety of chemotherapeutic agents and there has been intense i...

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Detalles Bibliográficos
Autores principales: Yang, Lanlan, Ritchie, Ann-Marie, Melton, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589656/
https://www.ncbi.nlm.nih.gov/pubmed/28903417
http://dx.doi.org/10.18632/oncotarget.19422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589656/
https://www.ncbi.nlm.nih.gov/pubmed/28903417
http://dx.doi.org/10.18632/oncotarget.19422

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