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Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation
Genetically engineered animal tumor models have traditionally been generated by the gain of single or multiple oncogenes or the loss of tumor suppressor genes; however, the development of live animal models has been difficult given that cancer phenotypes are generally induced by somatic mutation rat...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589658/ https://www.ncbi.nlm.nih.gov/pubmed/28903419 http://dx.doi.org/10.18632/oncotarget.19424 |