Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists

The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersensitivity characteristic of some types of neuropathic pain, as well as in cancer. Consequentl...

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Detalles Bibliográficos
Autores principales: de la Torre-Martínez, Roberto, Bonache, M. Angeles, Llabrés-Campaner, Pedro J., Balsera, Beatriz, Fernández-Carvajal, Asia, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Pérez de Vega, M. Jesús, González-Muñiz, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589751/
https://www.ncbi.nlm.nih.gov/pubmed/28883526
http://dx.doi.org/10.1038/s41598-017-10913-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589751/
https://www.ncbi.nlm.nih.gov/pubmed/28883526
http://dx.doi.org/10.1038/s41598-017-10913-x

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