Cargando…
Tertiary and quaternary structural basis of oxygen affinity in human hemoglobin as revealed by multiscale simulations
Human hemoglobin (Hb) is a benchmark protein of structural biology that shaped our view of allosterism over 60 years ago, with the introduction of the MWC model based on Perutz structures of the oxy(R) and deoxy(T) states and the more recent Tertiary Two-State model that proposed the existence of in...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589765/ https://www.ncbi.nlm.nih.gov/pubmed/28883619 http://dx.doi.org/10.1038/s41598-017-11259-0 |