Isoniazid Killing of Mycobacterium smegmatis NADH Pyrophosphatase Mutant at Single-Cell Level using Microfluidics and Time-Lapse Microscopy

We introduce single-cell analysis for isoniazid-treated Mycobacterium smegmatis mutant, msm1946-NADH pyrophosphatase, using microfluidics and automated time-lapse microscopy. Mycobacterial NADH pyrophosphatase isoforms play an important role for the mechanism of isoniazid and ethionamide activation....

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Detalles Bibliográficos
Autor principal: Elitas, Meltem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589797/
https://www.ncbi.nlm.nih.gov/pubmed/28883607
http://dx.doi.org/10.1038/s41598-017-11503-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589797/
https://www.ncbi.nlm.nih.gov/pubmed/28883607
http://dx.doi.org/10.1038/s41598-017-11503-7

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