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Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

Sepsis induced loss of muscle mass and function contributes to promote physical inactivity and disability in patients. In this experimental study, mice were sacrificed 1, 4, or 7 days after cecal ligation and puncture (CLP) or sham surgery. When compared with diaphragm, locomotor muscles were more p...

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Detalles Bibliográficos
Autores principales: Morel, Jérome, Palao, Jean-Charles, Castells, Josiane, Desgeorges, Marine, Busso, Thierry, Molliex, Serge, Jahnke, Vanessa, Del Carmine, Peggy, Gondin, Julien, Arnould, David, Durieux, Anne Cécile, Freyssenet, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589872/
https://www.ncbi.nlm.nih.gov/pubmed/28883493
http://dx.doi.org/10.1038/s41598-017-11440-5