Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized copy-number and methylation in over 280 cancer cell lines and confirm our observations in primary tumors. Imprinted differentially methylated regions (DMRs)...

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Detalles Bibliográficos
Autores principales: Martin-Trujillo, Alex, Vidal, Enrique, Monteagudo-Sánchez, Ana, Sanchez-Delgado, Marta, Moran, Sebastian, Hernandez Mora, Jose Ramon, Heyn, Holger, Guitart, Miriam, Esteller, Manel, Monk, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589900/
https://www.ncbi.nlm.nih.gov/pubmed/28883545
http://dx.doi.org/10.1038/s41467-017-00639-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589900/
https://www.ncbi.nlm.nih.gov/pubmed/28883545
http://dx.doi.org/10.1038/s41467-017-00639-9

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