Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions

Protein-based biosensors or activators have been engineered to visualize molecular signals or manipulate cellular functions. Here we integrate these two functionalities into one protein molecule, an integrated sensing and activating protein (iSNAP). A prototype that can detect tyrosine phosphorylati...

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Detalles Bibliográficos
Autores principales: Sun, Jie, Lei, Lei, Tsai, Chih-Ming, Wang, Yi, Shi, Yiwen, Ouyang, Mingxing, Lu, Shaoying, Seong, Jihye, Kim, Tae-Jin, Wang, Pengzhi, Huang, Min, Xu, Xiangdong, Nizet, Victor, Chien, Shu, Wang, Yingxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589908/
https://www.ncbi.nlm.nih.gov/pubmed/28883531
http://dx.doi.org/10.1038/s41467-017-00569-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589908/
https://www.ncbi.nlm.nih.gov/pubmed/28883531
http://dx.doi.org/10.1038/s41467-017-00569-6

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