Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3

Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-chan...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwamoto, Masayuki, Sumino, Ayumi, Shimada, Eri, Kinoshita, Masanao, Matsumori, Nobuaki, Oiki, Shigetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589915/
https://www.ncbi.nlm.nih.gov/pubmed/28883505
http://dx.doi.org/10.1038/s41598-017-11135-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589915/
https://www.ncbi.nlm.nih.gov/pubmed/28883505
http://dx.doi.org/10.1038/s41598-017-11135-x

Ejemplares similares